Gazyvaro (Obinutuzumab) prices, buy, information

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3,995.00

Gazyvaro made in Germany. We buy in pharmacies in Germany, included a check of the German pharmacy

150 в наличии

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Описание

What is Gazyvaro and how is it used?

What's Gazyvaro?

Gazyvaro contains the active substance obinutuzumab, which belongs to a group of medicines called "monoclonal antibodies". act antibody by binding to specific targets in the body.

What is it used Gazyvaro?

  • Gazyvaro is used together with another anticancer medicine called chlorambucil for the treatment of chronic lymphocytic leukemia (CLL).CLL is a cancer of the blood of the white blood cell - the so-called "B lymphocytes" - are affected. The affected B-lymphocytes multiply too quickly and live too long. This means that too many of them are present in your blood. CLL can also cause that your lymph nodes swell. Lymph nodes are part of a vascular network that is present in your body and with a clear, aqueous liquid which is "lymph" filled.

Gazyvaro is used in adult patients:

  • who have previously not received any treatment and
  • have other health problems, due to which they were a full dose of another anticancer drug called fludarabine probably not tolerated.

What makes Gazyvaro?

Gazyvaro attaches itself to targets on the surface of the "B-lymphocyte" and means that they die. In CLL patients, it is administered together with chlorambucil to stop the worsening of their disease

What you need to consider before using it?

Gazyvaro should not be used:

  • if you are allergic to obinutuzumab or any of the listed in section 6 excipients of the formulation.

If you are not sure, ask your doctor or nurse.

Warnings and Precautions

Please talk to your doctor or health care professional before using Gazyvaro if:

  • You have an infection or had a long-lasting or recurrent infection
  • Have you ever used drugs that affect your immune system (such as chemotherapeutic agents or drugs that suppress your immune system)
  • You are taking medicines for high blood pressure or blood thinning drugs - your doctor may change the use of these medicines
  • You have ever had heart problems
  • You have ever had neurological problems (memory loss, difficulty moving or sensation, visual disturbances)
  • You ever had difficulty breathing or lung problems
  • You ever had a liver disease, called hepatitis B had,
  • They should be vaccinated or in the near future is imminent vaccination.

Please talk to your doctor or health care professional before using Gazyvaro if any of these apply (or you are not sure).

infusion reactions

Tell your doctor or healthcare professional immediately if you experience an infusion reactions listed in Section 4 at the beginning occurs. Infusion reactions can occur in the 24 hours after the infusion during the infusion or at any time.

If infusion reactions occur to you, you may need additional treatment or the infusion may need to be slowed or stopped. When the symptoms disappear or improvement occurs, the infusion can be continued. During the second and subsequent infusions is the probability that these reactions occur less. Your doctor may decide that treatment with Gazyvaro not continue if you have a strong infusion reaction.

Before each infusion Gazyvaro you get drugs that help, potential infusion reactions or potentially life-threatening complication, known as tumor lysis syndrome mitigate. A tumor lysis syndrome is triggered by chemical disturbances in the blood caused by the breakdown of dying cancer cells (see section 3).

Progressive multifocal leukoencephalopathy (PML)

The progressive multifocal leukoencephalopathy (PML) is a rare and life-threatening encephalitis, have been reported among Gazyvaro.

Share if you notice your doctor or health care professional immediately with a memory loss, communication problems, difficulty walking or loss of vision at all times. If these symptoms have occurred to you before treatment with Gazyvaro, tell your doctor immediately about any changes in these symptoms. You may need medical treatment.

Children and adolescents

This medicine should not be used in children or adolescents below 18 years since there is no information on its use in this age group.

Application of Gazyvaro with other medicines

Tell your doctor or health care professional if you are taking other medicines, have recently taken any other medicines or might take any other medicines. This includes herbal medicines and other non-prescription medicines.

prevention

If you could get pregnant, you need while you are being treated with Gazyvaro and also for 18 months with Gazyvaro use effective contraception after your last treatment.

pregnancy

If you are pregnant or if you think you may be pregnant or intend to become pregnant, ask before using this medicine your doctor or health care professional for advice. Your doctor will benefits to you by applying Gazyvaro during pregnancy against the risk posed by your baby weigh. If you become pregnant during treatment with Gazyvaro, tell your doctor at once or the health care professional, since treatment with Gazyvaro affect your health or your baby could have.

lactation

During treatment with Gazyvaro and 18 months after the last treatment with Gazyvaro You should not breastfeed because small amounts of the drug can pass into your breast milk.

Driving and using machines

It is unlikely that Gazyvaro impair your ability to drive by car or bicycle or your ability to drive or operate machinery. However, infusion reactions are very common during the first infusion. If you experience an infusion reaction occurs (see section 4), you should not participate actively driving or operating machinery until the reaction subsides

How is it used?

Gazyvaro is administered under the supervision of a physician experienced in the treatment physician. It is administered over several hours into a vein (intravenously) as a drip (infusion).

The dosage of Gazyvaro

You will receive 6 cycles with Gazyvaro. Each cycle covers 28 days. On Day 1 of your first cycle you very slowly 100 mg Gazyvaro be administered and your doctor will monitor you carefully. If you show no infusion reaction during the infusion, can you (900 mg) can be administered on the first day of the rest of your first dose. However, if you experience an infusion reaction, you the rest of the first dose is administered on day. 2 A typical treatment regimen is shown below:

Your first cycle:

Day 1 - 100 mg
Day 2 or Day 1 (continued) - 900 mg
  • Day 8 - 1000 mg
  • Day 15-1000 mg

Their next cycles 2, 3, 4, 5 and 6:

  • Day 1 - 1000 mg

Drugs which are administered prior to each infusion

Before each infusion of Gazyvaro get medicines, may reduce the potential infusion reactions or tumor lysis syndrome. The following drugs can be obtained by:

  • liquids
  • Medicines for allergic reactions (antihistamines)
  • Medicines for inflammation (corticosteroids)
  • Painkillers (analgesics)
  • Medicines for fever
  • Medicines for the prevention of tumor lysis syndrome (such as allopurinol)

If you forget to use Gazyvaro

This cancer treatment can have an optimal effect, it is very important to follow the dosing schedule. So, do as quickly as possible to give a new date, if you have missed your appointment.

If you have any further questions on the use of this medicine, contact your doctor or health care professional.

What are the possible side effects?

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following serious adverse reactions have been reported for this medicine:

Infusion reactions (very common - can more than 1 in 10 patients treated): Apply immediately to your doctor or health care professional if any of the following symptoms within 24 hours occurs after your infusion:

Most commonly reported:

  • a headache
  • Fever, flushing or chills
  • Nausea, vomiting
  • shortness of breath
  • low or high blood pressure
  • palpitations
  • diarrhea

Less commonly reported:

  • wheezing, difficulty breathing, tightness in the chest or irritation in the throat
  • Swelling of the throat and airways
  • irregular heartbeat

If any of the symptoms listed above, contact your doctor immediately or nurse.

Progressive multifocal leukoencephalopathy (PML)

The progressive multifocal leukoencephalopathy (PML) is a rare and life-threatening encephalitis, have been reported among Gazyvaro.

Tell your doctor or healthcare professional immediately if you

  • a memory failure
  • communication difficulties
  • Difficulty walking
  • loss of vision

suffer. If these symptoms have occurred to you before treatment with Gazyvaro, tell your doctor immediately about any changes in these symptoms. You may need medical treatment.

infections

It may be that you are more susceptible to infections after treatment with Gazyvaro. Often these are colds, but also cases of heavier infections occurred. The recurrence of hepatitis B, a liver disease, has been reported in patients who have already had in the past, a hepatitis B.

Inform if you get your doctor for treatment with Gazyvaro symptoms of infection, for example,

  • fever
  • to cough
  • Sore throat
  • burning pain during urination
  • if you feel weak or generally unwell.

Other possible side effects include:

Very common (may be more than 1 of 10 patients treated):

  • fever
  • diarrhea
  • Results in blood tests:
    • low neutrophil (a type of white blood cell)
    • low platelet counts (a type blood cells, which is involved in blood clotting)
  • Anemia (low red blood cell count)

Common (may affect up to 1 in 10 patients treated):

  • urinary infection
  • Cold sores (herpes)
  • runny nose
  • Inflammation of the nose and / or throat
  • to cough
  • Joint or back pain
  • Musculoskeletal chest pain
  • increase in weight
  • irregular heart rhythm (atrial fibrillation)
  • hair loss
  • Skin cancer (squamous cell)
  • constipation
  • Results in blood tests:
    • low lymphocyte count (a type of white blood cell)
    • Low numbers of all types of white blood cells (combined)
    • Increase of potassium, phosphate or uric acid - can lead to kidney problems (part of tumor lysis syndrome)

Reporting of adverse reactions

If you notice any side effects, talk to your doctor or health care professional. This includes any possible side effects not listed in this leaflet.You may experience side effects directly via the in Annex V show listed national reporting system. By reporting side effects, you can help ensure that more information is provided about the safety of this product available

How should it be stored?

Gazyvaro is kept in the doctor's office or hospital. The storage conditions are listed below:

  • Keep this medicine out of reach of children.
  • Do not use X after the expiry date stated on the carton and on the label after "EXP" not use. The expiry date refers to the last day of that month.
  • In a refrigerator (2 ° C - 8 ° C). Do not freeze.
  • Keep the vial in the outer carton to protect from light.

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