Abraxane (Paclitaxel)


Abraxane made in Germany. We buy in pharmacies in Germany, included a check of the German pharmacy

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What is Abraxane and what is it used for?

Abraxane is a medicine containing paclitaxel albumin. Albumin is a constituent of human blood. Paclitaxel belongs to the group of medicines called taxanes used to treat cancer.

Abraxane is used to treat breast cancer when other therapies have been tried but have not been successful, and if you do not qualify for anthracycline-containing therapy in question.

What you need to consider before using it?

Abraxane should not be used,

  • if you are hypersensitive (allergic) to paclitaxel or any of the other ingredients of Abraxane;
  • if you are breastfeeding;
  • if your white blood cells are decreased (baseline neutrophil counts of <1.5 x 109 / l - your doctor will tell you).

Take special care with the use of Abraxane is required:

  • if you have poor kidney function;
  • if you experience numbness, tingling, tingling sensation, sensitivity to touch or muscle weakness occurs;
  • if you suffer from severe liver problems;
  • if you have heart problems;
  • if you develop breathing problems such as shortness of breath or dry cough.

If any of these conditions to your home, your doctor may stop treatment or reduce the dose possibly.

Using Abraxane with other medicinal products

Please inform your doctor if you take other medicines / taking or have recently taken /, even if it is not prescribed, as they could possibly cause an interaction with Abraxane.

Using Abraxane with food and beverages

Food and drink do not affect Abraxane.

pregnancy and breast feeding period

Paclitaxel probably caused serious birth defects and should therefore not be used in case of pregnancy.

Women of childbearing potential should use effective contraception during and up to 1 month after treatment with Abraxane. Male patients treated with Abraxane is advised, during and up to six months to father a child after treatment. They should seek advice based on the treatment of sperm preservation, because there through the Abraxane treatment, the possibility of permanent infertility.

It is not known whether paclitaxel is excreted in human milk. Due to the potential harmful effects to the infant, breast-feeding should be discontinued during treatment.

Ask. Before taking this medicine your doctor for advice

Driving and using machines

Abraxane may cause side effects such as tiredness (very common) and dizziness (common) that may affect the ability to drive and the ability to operate machinery. If such symptoms occur, do not drive or operate machinery until they are completely gone.

If you receive other medicines as part of your treatment, you should take advice regarding driving or operating machinery by your doctor.

Important information about some of the ingredients of Abraxane

A dose of the drug contains about 425 mg sodium. If you are on a controlled sodium diet, you should take this into account.

How is it used?

Abraxane is given to you by a doctor or a nurse from a bag into a vein. The dose you receive is based on the size of your body surface area and on the results of blood tests. The usual dose is 260 mg per m2 body surface.

How often will you receive Abraxane?

Abraxane is usually given every three weeks.

How long is the intravenous infusion on you?

Abraxane is added over a period of 30 minutes.

If you have any further questions on the use of this product, ask your doctor.

What are possible side effects?

Like all medicines, Abraxane side effects, although not everybody gets them.

The frequency of possible side effects listed below is defined using the following convention:

Very common (affects more than 1 in 10 patients), common (affects 1 to 10 patients in 100) uncommon (affects 1 to 10 in 1,000 patients), rare (affects 1 in 10 of 10,000 patients),

very rare (affects less than 1 in 10,000 patients),

not known (based on the available data can not be estimated).

The very common side effects are:

  • Hair loss, skin rash
  • Abnormal reduction in blood neutrophil counts
  • Reduction of white blood cells in the blood
  • Lack of red blood cells
  • Reduction of lymphocytes in the blood
  • Decrease of platelets in the blood
  • Impact on the peripheral nerves (pain and numbness)
  • Pain in one or more joints
  • Pain in the muscles
  • Nausea, diarrhea, constipation, mouth sores, loss of appetite
  • Vomit
  • Weakness and fatigue, fever

The common side effects are:

  • Itching, dry skin, nail disorder
  • Infection, fever with decrease in the number of neutrophils in the blood, flushing with heat sensation
  • Chest, throat or abdominal pain, headache
  • Indigestion, abdominal discomfort
  • difficulty breathing
  • Dehydration, taste disturbance, weight loss, hypokalaemia
  • Pain in the extremities, back or limbs, bone pain, muscle spasms
  • Dizziness, reduced muscle coordination or difficulty in reading, increased or decreased tear production, falling out of eyelashes
  • Change in heart rate or heart rhythm
  • Swelling of the mucous membranes or soft tissues
  • Insomnia, depression, anxiety
  • Increase in liver enzymes

Occasional side effects include:

  • Increased blood pressure, weight gain, increase in lactate in the blood, impaired kidney function, increased blood sugar, increased phosphate in the blood, decreased blood potassium levels
  • Nerve disorders, decreased or absent reflexes, involuntary movements, pain along a nerve, loss of touch, fainting, dizziness on standing, painful numbness or tingling, tremors
  • Irritated eyes, painful eyes, red eyes, itchy eyes, blurred or double vision, reduced vision, or seeing flashing light
  • Ear pain, tinnitus
  • Productive cough, shortness of breath when walking or climbing stairs, stuffy nose, runny nose, or dry nose, decreased breath sounds, water in the lungs, loss of voice, difficulty breathing, dry cough, blood clot in the lung
  • Difficulty swallowing, flatulence, dry mouth, liquid stools, heartburn, stomach cramps, painful or sore mouth or aching or sore gums, rectal bleeding
  • comply Painful urination, frequent urination, blood in the urine, inability to urine
  • Fingernail pain; Fingernail discomfort, fingernail loss, hives, skin pain, red skin from sunlight, skin discoloration, red rash, itchy rash, increased sweating, night sweats, white areas on the skin, less hair growth, general itching, sores, aufgeschwollenes face
  • Reduced phosphorus levels in the blood, fluid retention, low albumin levels in the blood, increased thirst, decreased calcium in the blood, reduced blood sugar levels, decreased blood sodium levels
  • Thrush, pain and swelling in the nose and throat, skin infections, infections in the lungs, infection due to catheter infection, redness or swelling at the site of entry of the needle into the skin
  • bruise
  • Pain at the tumor site, Tumorabsterben
  • Decreased blood pressure, low blood pressure when standing up, cold hands and feet
  • Pain or pressure in the chest, difficulty walking, swelling
  • Allergic reaction
  • Decreased liver function, enlarged liver
  • Chest pain
  • restlessness

The rare side effects are:

  • Decrease in blood cells
  • lung infection
  • Skin reaction to a substance or pneumonia other after irradiation
  • blood clot
  • Stark slowed pulse, heart attack, heart failure
  • Leakage of drug out of the vein

The rare side effects are:

  • Severe inflammation / severe rash of the skin and mucous membranes (Stevens-Johnson syndrome, toxic epidermal necrolysis)

Please inform your doctor if any of you side effects gets serious, or you notice any side effects not listed in this leaflet.

How should it be stored?

Store drug out of reach of children.

You may use after the according to the carton and vial

, EXP 'stated expiration date no longer apply. The expiry date refers to the last day of the month.

Unopened vials: This medicinal product temperature No special storage conditions are required with respect. Keep the vial in the outer carton to protect from light.

After first reconstitution, the suspension should be used immediately. If not used immediately, it can in the vial up to 8 hours in the refrigerator be stored (2 ° C-8 ° C) when it is kept in the outer carton to protect from light.

In the infusion bag, the reconstituted suspension may be stored at a maximum of 25 ° C up to 8 hours.


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