Epclusa

16,950.00

Packaged 28 st. Provided a cash receipt from the German pharmacy, delivery to your home.

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Описание

EPCLUSA (sofosbuvir 400 mg/velpatasvir 100 mg) buy in Germany

EPCLUSA 400 mg / 100 mg film-coated tablets
Contents: 28 pieces, N1
provider: Gilead Sciences GmbH
Pharmaceutical form: film-coated tablets

additional information

application areas

Which illnesses is this medication used for?

  • The medicinal product is a medicinal product containing the active substances Sofosbuvir and Velpatasvir in a single tablet. It is used to treat chronic (long-term) viral infection of the liver, referred to as hepatitis C infection, in adults over 18 years of age.
  • The active ingredients contained in this medicinal product work together by blocking two different proteins (proteins) that the virus needs to grow and multiply, thus permitting a permanent elimination of infection from the body.
  • The medicine is sometimes taken with another medicine, ribavirin.
  • It is very important that you also read the package inserts of the other medicines you are going to take with the product. If you have any questions about your medicines, please consult your doctor or pharmacist.

Application notes

How is the medicine used?

  • Warnings and Precautions
    • Please talk to your doctor if you:
      • Other liver problems other than hepatitis C, eg
        • If you have hepatitis B, as your doctor may then want to monitor you more closely;
        • If you have received a liver transplant;
      • Kidney problems, since the drug has not been fully investigated in patients with severe renal problems;
      • Medicines for infection with human immunodeficiency virus (HIV), as your doctor may want to monitor you more closely.
    • Please tell your doctor or pharmacist before taking this medicine if:
      • You are taking or have recently taken the medicine amiodarone for the treatment of cardiac arrhythmia (if you have taken this medicine, your doctor may consider alternative treatments).
    • Inform your doctor immediately if you are taking any medicine for heart problems and if you notice the following symptoms during the treatment:
      • shortness of breath
      • dizziness
      • heart palpitations
      • Pass out
    • Blood tests
      • Your doctor will perform blood tests before, during and after the treatment. This is done so that:
        • Your doctor can decide if you should take the medicine and for how long;
        • Your doctor can confirm that your treatment has been successful and no hepatitis C virus is present in your body.
    • Children and adolescents
      • Do not take this medicine with any of the following: The use in children and adolescents has not yet been investigated.
  • Ability to drive and operate machines
    • The medicine should not interfere with your ability to drive or operate machines.

What is to be considered additionally?

  • Swallow the tablet whole with or without food. The tablet should not be chewed, crushed or split, since it has a very bitter taste.
  • If you are taking an antacid, take it at least 4 hours before or at least 4 hours after the preparation.
  • If you are taking a proton pump inhibitor, take the medicine with a meal.

dosage

How often and in what quantities is the medicine used?

  • Always take this medicine exactly as prescribed by your doctor. Ask your doctor or pharmacist if you are not sure.
  • Recommended dose
    • The recommended dose is one tablet once daily for 12 weeks.
  • If you feel bad (after passing), this can affect the amount of active substance in your blood. This can mitigate the effect.
    • If you are taking less than 3 hours after your dose, take another tablet.
    • If you are more than 3 hours after taking this medication, do not take another tablet until your next scheduled intake.
  • If you have taken more than you should
    • If you accidentally miss a dose that is larger than the recommended dose, consult your doctor or emergency department immediately for advice. Take the bottle with the tablets so you can easily describe what you have taken.
  • If you forget to take this medicine
    • It is important not to miss a dose of this medicine.
    • If you miss a dose, take the time to take the medicine for the last time:
      • If you notice this within 18 hours of the usual intake, you must take the tablet as soon as possible. Then take the next dose at your usual time.
      • If you notice this later than 18 hours after the usual intake, wait and take the following dose at the usual time. Do not take a double dose (two doses, one after the other).
  • Do not stop taking.
    • Do not stop taking this medicine, unless directed to do so by your doctor. It is very important that you go through the treatment cycle completely, so that the medicine can fight your hepatitis C virus infection optimally.
    • If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Contraindications

In which cases should not the medicine be used?

  • The medicinal product must not be taken,
    • If you are allergic to Sofosbuvir, Velpatasvir or any of the other ingredients in this medicine.
      • If this applies to you, do not take the drug and inform your doctor immediately.
    • If you are currently taking any of the following medicines:
      • Rifampicin and rifabutin (antibiotics for the treatment of infections, including tuberculosis);
      • St. John's Wort (Hypericum perforatum - a herbal medicine for the treatment of depression);
      • Carbamazepine, phenobarbital and phenytoin (medicines for the treatment of epilepsy and prevention of seizures);

What applies during pregnancy and breastfeeding?

  • Pregnancy and contraception
    • The effects during pregnancy are not known. If you are pregnant, or if you suspect you are pregnant or intend to become pregnant, consult your doctor before taking this medicine.
    • The medicine is sometimes used together with ribavirin. Ribavirin can harm your unborn child. It is therefore very important that you (or your partner) do not become pregnant during this treatment or after a period of time after treatment. Read the "Pregnancy" section of Ribavirin's package leaflet carefully. Ask your doctor for a reliable method of prevention that is appropriate for you and your partner.
  • Breastfeeding
    • Do not breastfeed during treatment. It is not known whether Sofosbuvir or Velpatasvir, the two active ingredients in the preparation, pass into the mother's milk.

Side effects

What side effects can occur for individual patients?

  • Like all medicines, this medicine can cause side effects, although not everybody gets them.
    • If you notice any side effects, contact your doctor.

What may interact with other medicines?

  • Ingestion together with other medicines
    • Tell your doctor or pharmacist if you are taking any other medicines, recently use other medicines, or intend to use other medicines. If you are not sure, ask your doctor or pharmacist.
    • Some medicines should not be taken with this combination drug:
      • Do not take any other medicines that contain Sofosbuvir, one of the active ingredients of the medicine.
      • Tell your doctor or pharmacist if you are taking any of the following medicines:
        • Amiodarone, which is used for the treatment of cardiac arrhythmias;
        • Rifapentin (antibiotic for the treatment of infections including tuberculosis);
        • Oxcarbazepine (medicines for the treatment of epilepsy and prevention of seizures);
        • Tenofovir disoproxil fumarate or other medicinal products containing tenofovir disoproxil fumarate for the treatment of HIV infection;
        • Efavirenz for the treatment of HIV infection;
        • For treating hereditary diseases;
        • Dabigatran for blood thinning;
        • Modafinil for the treatment of sleep disorders;
        • Rosuvastatin or other statins for the treatment of high cholesterol.
    • Ingestion together with any of these medicines may cause them to become ineffective or cause digoxines to aggravate side effects. It may be necessary for your doctor to prescribe another medicine or to adjust the dose of the medicines used at the same time. This change may affect the preparation or any other medicinal product you are taking.
    • Ask your doctor or pharmacist for advice if you are taking any medicine for the treatment of stomach ulcers, heartburn or reflux disease, as they can cause a reduction in the amount of velpatasvir in your blood. This medicinal product includes:
      • Antacids (eg, aluminum / magnesium hydroxide or calcium carbonate).These should be taken at least 4 hours before or 4 hours after the combination preparation;
      • Proton pump inhibitors (eg, omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole). The medicine should be taken with a meal if a proton pump inhibitor is taken.
      • H 2 -receptor antagonists (eg. As famotidine, cimetidine, nizatidine or ranitidine). If you need high doses of these medicines, your doctor may prescribe another medicine or change your drug dose accordingly.
    • These medicines can cause a reduction in the amount of velpatasvir in your blood. If you are taking any of these medicines, your doctor will either prescribe another medicine for the treatment of stomach ulcers, heartburn or reflux disease, or give you recommendations on the type and time of taking such medicines.

composition

What is included in the medicine?

Active ingredient Sofosbuvir 400mg
Active ingredient Velpatasvir 100mg
Excipient Cellulose, microcrystalline +
excipient copovidone +
Croscarmellose, sodium salt +
Excipient Iron (III) oxide +
adjuvant Macrogol +
Excipient magnesium stearate +
Adjuvant poly (vinyl alcohol) +
excipient talc +
Excipient titanium dioxide +

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