Kyprolis (carfilzomib)


Kyprolis 60 mg buy in the German pharmacy, cashier’s check attached. Express delivery from Germany

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What is Kyprolis and how is it used?

Kyprolis is a medicine that contains the active substance Carfilzomib.

Carfilzomib acts by blocking the proteasome. The proteasome is a system within cells that degrades proteins when these are damaged or are no longer needed. Through prevention of protein degradation in cancer cells, which is a higher probability that they contain more abnormal proteins Kyprolis leads to the death of cancer cells.

Kyprolis is used to treat adult patients with multiple myeloma who have received at least one previous treatment for this disorder. Multiple myeloma is a cancer of plasma cells (a type of white blood cell).

Kyprolis is given to you along with lenalidomide and dexamethasone.These are other drugs that are used for the treatment of multiple myeloma

What you need to consider before using it?

Your doctor will examine you and check your complete medical history.They are carefully monitored during treatment. Before applying Kyprolis and during treatment, your blood will be analyzed. This is done to ensure that you have a sufficient number of blood cells and that your liver and kidneys are working properly. Your doctor or nurse will make sure that you get enough fluids.

You must read the leaflet of all medicines that you use in combination with Kyprolis to help you understand the information relating to these medicines.

Kyprolis should not be used if you are allergic to Carfilzomib or any of the listed in section 6 excipients of the formulation.

Warnings and Precautions

Please talk to your doctor or health care professional before using Kyprolis if you have one of the below disorders. It must at you may have additional tests are performed to check whether your heart, your kidneys and liver are working properly.

  • Heart problems, including a history of chest pain (angina), heart attack and irregular heartbeat, or if you have ever taken drugs for your heart.
  • Lung problems, including a history of shortness of breath at rest or with activity (dyspnea).
  • Kidney problems, including kidney failure, or if you have ever had a dialysis.
  • Liver problems, including a history of hepatitis or fatty liver disease, or if you ever said that your liver is not working properly.
  • Unusual bleeding, including rapid emergence of bruising, bleeding from injuries, such as a section in which it takes longer than expected until the bleeding stops. . Or internal bleeding such as the coughing up blood, vomiting blood, dark tarry stools or bright red blood in your stools; or bleeding in the brain that lead to sudden numbness or paralysis on one side of your face, your legs or arms, sudden severe headache or problems with vision or difficulty speaking or swallowing. This could indicate that you have a low number of platelets (cells that promote blood clotting).
  • A history of blood clots in your veins.
  • Pain or swelling of the legs or arms (these may be symptoms of blood clots in the deep veins of legs or arms), chest pain or shortness of breath (which may be symptoms of blood clots in the lungs).
  • Any other serious illness that required hospitalization or for which you have received Any medicines.

Complaints to which you must pay attention

While you apply Kyprolis, you must look out for certain symptoms to reduce the risk of any problems. Kyprolis can worsen some existing symptoms or cause serious side effects that can be fatal such. B.

Heart problems, lung problems, kidney problems, tumor lysis syndrome (a life-threatening disease that occurs when cancer cells break down and their contents proposed in the bloodstream), reactions to the Kyprolis infusion, unusual bruising or bleeding (including internal bleeding), blood clots in your veins , liver problems, certain blood disorders or a known as PRES neurological disorder. See "ailments to which you should pay attention" in section. 4

Application of Kyprolis with other medicines

Tell your doctor if you are taking other medicines, have recently taken any other medicines or might take any other medicines. This also applies to all non-prescription medicines, such. As vitamins and herbal medicines.

Tell your doctor or health care professional know if you are taking medicines to prevent pregnancy, such as oral contraceptives or other hormonal contraceptives, as these may not be suitable for use in conjunction with Kyprolis.

pregnancy and breast feeding period

For women using Kyprolis

Apply Kyprolis not to, if you are pregnant, or if you think you may be pregnant or intend to become pregnant. Treatment with Kyprolis has not been studied in pregnant women. While you apply Kyprolis and for 30 days after cessation of treatment, you should apply an appropriate contraception to ensure that you are not pregnant. You should talk to your doctor or health care professional about appropriate methods of contraception.

If you become pregnant while using Kyprolis, immediately notify your doctor or nurse.

Apply Kyprolis not if you are breastfeeding. It is not known whether Kyprolis is excreted in human breast milk.

It is expected that lenalidomide harm to the unborn child. Since Kyprolis is used in combination with lenalidomide, you must participate in the Pregnancy Prevention Programme (see leaflet of lenalidomide for information on contraception, please discuss this with your doctor, pharmacist or health care professional).

For men who apply Kyprolis

While you apply Kyprolis and for 90 days after cessation of treatment, you should use a condom in order to ensure that your partner is not pregnant.

Inform your doctor or health care professional if your partner while you apply Kyprolis or within 90 days after discontinuation of treatment, should be pregnant.

Driving and using machines

While you are being treated with Kyprolis, you may experience fatigue, dizziness, fainting, and / or a drop in blood pressure. This could affect your ability to drive and your ability to operate machinery. Do not drive or operate machinery if these symptoms occur.

Kyprolis contains sodium

This medicinal product contains 0.3 mmol sodium (equivalent to 7 mg sodium) per ml of reconstituted (for immediate usage) solution. If you are on a controlled sodium diet, you should take this into account.

How is it used?

Kyprolis is given to you by your doctor or nurse. The dose is calculated from your height and your weight (body surface area). Your doctor or nurse will determine the dose Kyprolis RECEIVED.

Kyprolis will be given by infusion into a vein. The infusion will last approximately 10 minutes. Kyprolis is given on 2 consecutive days per week for 3 weeks followed by one week without treatment.

Each period of 28 days corresponds to a treatment cycle. That is, Kyprolis you will be given on days 1, 2, 8, 9, 15 and 16 of each 28-day cycle. The doses at day 8 and 9 of each cycle accounts from the 13th cycle.

Most patients receive treatment for as long as their disease improves or remains stable. However, treatment with Kyprolis can also be terminated if you get side effects that are not manageable.

Together with Kyprolis also lenalidomide and dexamethasone is given to you. They could also be given other medicines.

If you have received a greater amount of Kyprolis than you should

This medicine is given by a doctor or nurse, it is unlikely that you will receive too much. If still too much Kyprolis was applied, your doctor will monitor you with regard to side effects.

If you have any further questions on the use of this medicine, ask your doctor or nurse

What are the possible side effects?

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Complaints to which you should pay

Some side effects can be severe. Please discuss with your doctor immediately if you notice any of the following symptoms:

  • Chest pain, shortness of breath or swelling of your feet, may be what symptoms of heart problems.
  • Breathing problems, including shortness of breath at rest or with activity or a cough (dyspnea), rapid breathing, a feeling as if you have enough air could not breathe, wheezing or coughing, which may be signs of pulmonary toxicity.
  • Very high blood pressure, severe chest pain, severe headache, confusion, blurred vision, nausea and vomiting or severe anxiety, may be what signs of disease, which is known as hypertensive crisis.
  • Shortness of breath with everyday activities or at rest, irregular heartbeat, racing pulse, fatigue, dizziness and fainting, may be what signs of a disease known as pulmonary hypertension.
  • Swollen ankles, feet or hands, loss of appetite, decrease in the amount of urine or laboratory abnormalities in blood tests, may be what symptoms of kidney problems or kidney failure.
  • A side-effect, the tumor lysis syndrome is named, which can be caused by the rapid disintegration of tumor cells and irregular heartbeat, kidney failure or abnormal blood test results may result.
  • Fever, chills or shivering, arthralgia, myalgia, facial flushing or -schwellung, weakness, shortness of breath, low blood pressure, fainting, chest tightness or chest pain may occur in response to the infusion.
  • Unusual bruising or bleeding, such as a section in which it takes longer than normal until it stops bleeding. . Or internal bleeding such as the coughing up blood, vomiting blood, dark tarry stools or bright red blood in your stools; or bleeding in the brain that lead to sudden numbness or paralysis on one side of your face, your legs or arms, sudden severe headache or problems with vision or difficulty speaking or swallowing.
  • Pain or swelling of the legs or arms (these may be symptoms of blood clots in the deep veins of legs or arms), chest pain or shortness of breath (which may be symptoms of blood clots in the lungs).
  • Yellow discoloration of your skin and eyes (jaundice), abdominal pain or swelling, nausea or vomiting, which are symptoms of liver problems, including liver failure, can be.
  • Bleeding, bruising, weakness, confusion, fever, nausea, vomiting and diarrhea, and acute renal failure, which may be signs of a blood disorder known as thrombotic microangiopathy.
  • Headache, confusion, convulsions (seizures), vision loss and high blood pressure (hypertension), which symptoms may be a neurological condition called posterior reversible encephalopathy syndrome (PRES) is known.

Other possible side effects

Very common side effects (may be more than 1 of 10 patients treated):

  • infusion reactions
  • Severe lung infection (pneumonia)
  • Infection of the respiratory tract (respiratory tract infection)
  • Runny or stuffy nose
  • Low platelet count which can result in increased Bluterguss- or bleeding (thrombocytopenia)
  • Low white blood cell count, which may affect your ability to fight infection diminish, and be accompanied by fever
  • Low red blood cell count (anemia), which can cause tiredness and fatigue
  • Changes in blood test results (decrease in potassium levels in the blood, increasing the sugar and / or creatinine levels in the blood)
  • decreased appetite
  • Sleeping (insomnia)
  • a headache
  • Numbness, tingling or decreased sensation in the hands and / or feet
  • dizziness
  • High blood pressure (hypertension)
  • shortness of breath
  • to cough
  • diarrhea
  • nausea
  • constipation
  • Vomit
  • stomach pain
  • back pain
  • joint pain
  • Pain in limbs, hands or feet
  • muscle twitching
  • fever
  • Swelling of the hands, feet or ankles
  • weakness
  • Fatigue (tiredness)

Common side effects (may affect up to 1 in 10 patients treated):

  • Heart failure and heart problems, including rapid, heavy or irregular heartbeat
  • Kidney problems, including kidney failure
  • Blood clots in the veins (deep venous thrombosis)
  • feeling hot
  • Blood clots in the lung
  • Fluid in the lungs
  • wheeze
  • Serious infections, including infection in the blood (sepsis)
  • Liver problems, including an increase in liver enzymes in the blood
  • Flu-like symptoms (influenza)
  • Urinary tract infection (infection of structures that urine derived)
  • may include cough, tightness or pain in the chest and nasal congestion (bronchitis)
  • Sore throat
  • Inflammation of the nose and throat
  • Viral infection
  • Changes in blood test results (decrease in sodium, magnesium, protein, calcium or phosphate levels in the blood, increasing the calcium, uric acid, potassium, bilirubin, or C-reactive protein levels in the blood)
  • dehydration
  • anxiety
  • Blurred vision
  • Lens opacity (cataract)
  • Low blood pressure (hypotension)
  • nosebleeds
  • Change of voice or hoarseness
  • indigestion
  • toothache
  • skin rash
  • Bone pain, muscle pain, chest pain
  • muscle weakness
  • aching
  • Itchy skin
  • Redness of the skin
  • Increased sweating
  • Pain
  • chills
  • Pain, swelling, irritation or discomfort at the location where you have received the injection into your vein

Uncommon side effects (may affect up to 1 in 100 patients treated):

  • Allergic reaction to Kyprolis
  • multiorgan failure
  • Heart attack
  • Decreased blood flow to the heart
  • Bleeding in the brain
  • stroke
  • Swelling of the surrounding heart tissue (pericarditis); Symptoms include pain behind the breastbone, which sometimes can spread to the neck and shoulders and sometimes accompanied by fever
  • Accumulation of fluid between the tissue surrounding the heart and your heart (pericardial effusion); Symptoms include chest pain or pressure in the chest and shortness of breath, a
  • A blockage in the bile drainage from the liver (cholestasis) which itchy skin, yellow skin, very dark urine and very pale stools can cause
  • Perforation of the digestive system

Reporting of adverse reactions

If you notice any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.

You can view side effects directly via the products listed in Annex V national reporting system. By reporting side effects, you can help ensure that more information is provided about the safety of this product available

How should it be stored?

Keep this medicine out of reach of children.

Kyprolis is stored in the pharmacy.

Do not use this medicine after the expiry date stated on the vial and the carton. The expiry date refers to the last day of that month.

Store in a refrigerator (2 ° C - 8 ° C). Do not freeze.

Store in the original package in order to protect from light.

The reconstituted product should be a clear, colorless to slightly yellow solution and not be administered if discolouration or particulate matter is present.

Kyprolis is only intended for single use. Not product or waste material should be disposed of in accordance with local requirements.


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