What is Lenvima 4 mg and how is it used?
Lenvima 4 mg (Lenvatinib) is a medicine containing the active substance Lenva tinib. It wi d for Behan dlung of Fortschr itendem he od advanced thyroid cancer at Erwa hsenen ang ewendet when treatment with radioactive iodine was no longer effective.
How does Lenvima 4 mg (Lenvatinib)?
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vorkom men. Since Lenvima 4 mg (Lenvatinib) blocked their action, kan it n the Wachstumsgesc hwindigkeit of cancer cells verlang amen and contribute to the f or this Kre bszellen not manoeuvrable blood supply is inhibited
What you need to consider before using it?
Lenvima 4 mg (Lenvatinib) may ni ht eingeno mmen be when
|You atinib allergic to Lenv or referred to in ection 6 so nstigen constituents|
|this drug are using.|
- You are breastfeeding (see Section "Empfängn isverhütung, pregnancy and S tillzeit" further u th).
Warnings and Precautions
Please talk to your doctor before taking Lenvima 4 mg (Lenvatinib) if you:
- have high blood pressure,
- a woman of childbearing age (see "contraception, pregnancy and breast-feeding" below)
- had in the past, heart problems or strokes,
- Liver and / or renal impairment have,
- have recently had surgery or radiotherapy,
- over 75 years old,
- different ethnic origin than white-skinned or Asian are,
- less than 60kg weigh.
Your doctor will talk to you about the following before taking Lenvima 4 mg (Lenvatinib):
- Side effects to your doctor must examine (hypertension, early signs of renal or hepatic dysfunction, heart problems and values of certain salts [low] and the thyroid stimulating hormone [increases] in your blood.
- Side effects, about which you must inform your doctor immediately (see section 4zu possible side effects).
Talk to your doctor if any of these options applies to you. You may require additional treatment with other medicines, or you need to take a lower dose of LENVIMA or need to be careful because of an increased risk of side effects.
If any of the above events apply to you (or if you are not sure), talk to your doctor before taking LENVIMA.
Children and adolescents
The use of LENVIMA in children and adolescents is not recommended.The effects of LENVIMA among young people under 18 years are not known.
Taking LENVIMA with other medicines
Tell your doctor or pharmacist if you are taking other medicines / apply, have recently taken / used any other medicines or intend to take / apply other medicines.
Contraception, pregnancy and lactation
- Apply highly effective contraceptive measures while taking this medicine, if the possibility exists that you could get pregnant, and put them after the end of treatment or for at least a month away. It is not known whether LENVIMA can reduce the effectiveness of oral contraceptives ( "the pill"). If the pill is your usual contraceptive measures, you should also use a barrier method such. As a Zervixkappe or condoms apply if you are using LENVIMA have intercourse during treatment.
- Do not take a LENVIMA if you plan to become pregnant during treatment. Lenvima 4 mg (Lenvatinib) could harm your baby difficult.
- If you become pregnant during treatment with LENVIMA, you immediately inform your doctor. Your doctor will decide with you whether treatment should be continued. You should not breastfeed if you are taking LENVIMA. This medicine may cause serious harm to your child.
Driving and using machines
LENVIMA can cause side effects, your ability to drive or your ability to operate machinery may affect. Avoid driving or using machines if you feel dizzy or feel tired
How is it used?
Take this medicine exactly as your doctor has told a. Ask yourself if you are not sure with your doctor or pharmacist.
How much is taken?
- The usual recommended dose of LENVIMA is 24 mg once daily (2 capsules of 10 mg and 1 capsule 4 mg).
- If you suffer from severe liver or kidney dysfunction, the recommended dose is 14 mg once daily (1 capsule 10 mg and 1 capsule 4 mg).
- Your doctor may reduce the dose if you have problems with side effects.
Taking the drug
- You can take the capsules with food or without food.
- Swallow the capsules whole with water.
- Take them always about the same time each day.
- Caregivers should avoid coming into contact with the contents of the capsule.
How long should LENVIMA be taken?
They will continue taking this medicine usually as long as you have a clinical benefit from the treatment.
If you take more of LENVIMA than you should
If you take more of Lenvima 4 mg (Lenvatinib) than you should, talk to a doctor or pharmacist. Take the medicine pack.
If you forget to take LENVIMA
What to do if you forget to take a dose, depends on how long it takes until you should take your next dose.
- If there are up to taking your next dose 12 hours or more, take a missed dose as soon as you remember. The next dose, take then on again at the usual time.
- If there are up to taking your next dose is less than 12 hours, skip the missed dose. The next dose, take then on again at the usual time.
Do not take a double dose (two doses at once) if you have forgotten dose.
What are the possible side effects?
Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may happen with this medicine.
Inform your doctor immediately if you notice any of the following side effects - you may need urgent medical treatment:
- Numbness or weakness on one side of the body, severe headache, seizures, confusion, difficulty speaking, blurred vision or dizziness.These may be signs of a stroke, cerebral hemorrhage or the impact of a strong rise in blood pressure on the brain.
- Chest pain or pressure in the chest; Pain radiating into the arms, in the back, neck, or jaw; Shortness of breath; rapid or irregular heartbeat; To cough; Bluish discoloration of lips or fingers; extreme tiredness -this may be signs of a heart problem or a blood clot in the lungs.
- Severe abdominal pain - they can be caused by a hole in the intestinal wall or through a fistula (a hole in the intestine, which is connected via a tubular connection with another part of the body or the skin).
- Black, tarry or bloody stools, or coughing up blood - these may be signs of bleeding in the body.
- Diarrhea, nausea and vomiting - these are very common side effects that can be serious if they cause you get dehydrated (lose too much water).This can lead to kidney failure. Your doctor may give you medicines to reduce these side effects.
Tell them immediately if you notice your doctor any of the above side effects occurs.
Other side effects include:
Very common (may affect more than 1 in 10 people)
- High and low blood pressure
- Loss of appetite or weight loss
- Nausea and vomiting, constipation, diarrhea, abdominal pain, indigestion
- Strong tiredness or weakness
- Swelling of the legs
- skin rash
- Dry, wonderful or inflamed mouth, dysgeusia
- Swelling and inflammation of joints and stiff muscles, bones and joints
- hair loss
- Bleeding (most commonly epistaxis, but also bleeding emanating from other parts of the body, such. As blood in the urine, bruising, bleeding gums or intestinal bleeding).
- sleep disorders
- Changes in urine tests for protein (high) and urinary tract infections (frequent urination and painful urination)
- Muscle and joint pain as well as headaches and back pain
- Redness, irritation and swelling of the skin on hands and feet (hand-foot syndrome)
- Altered blood potassium (low) and calcium (low)
- Bruises and difficult wound healing - signs of low blood platelet levels in the blood
Common: (may affect up to 1 in 10 patients treated)
- Loss of body fluids (dehydration)
- Dry skin, skin thickening and itching of the skin
- Geblähtsein or bloating
- Heart problems or blood clots in the lungs (shortness of breath, chest pain) or other organs
- Anal fistula (forming a narrow channel between the anus and surrounding skin)
- Changes in blood levels of liver, kidney and white blood cells (low), sodium and magnesium (low) and thyroid-stimulating hormone (high)
- kidney failure
Uncommon (may affect up to 1 in 100 patients treated)
- Painful infection or irritation near the anus
- Small stroke
- liver damage
- Severe pain in the left upper abdomen (), which can be accompanied by fever, chills, nausea and vomiting.
Reporting of adverse reactions
If you notice any side effects, contact your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can view side effects directly via the products listed in Annex V national reporting system. By reporting side effects, you can help ensure that more information is provided about the safety of this product available
How should it be stored?
- Keep this medicine out of reach of children.
- Do this medicine after the on the carton after "EXP" and on each blister after "EXP. to "expiration date no longer use. The expiry date refers to the last day of that month.
- Below 25 ° C. Store in the original blister in order to protect from moisture.
- Do not dispose of medicines via wastewater or household waste. Ask your pharmacist how to dispose of medicines when you are done using it. These measures will help to protect the environment.